Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Rutin Powder (non-citrus source)(Sophora japonica) (Flower Bud)
450 mg
*
Top Medical Research Studies
9
We aimed to investigate how rutin might help manage psoriasis and its underlying mechanisms. By utilizing network pharmacology, we identified 62 potential targets of rutin relevant to psoriasis and assessed its impact on severity using a murine model.
Our results demonstrated that rutin significantly reduced severity scores and improved skin lesions compared to the control group. Furthermore, we found a decrease in key inflammatory mediator levels, indicating that rutin could effectively modulate various inflammatory pathways involved in psoriasis.
Our results demonstrated that rutin significantly reduced severity scores and improved skin lesions compared to the control group. Furthermore, we found a decrease in key inflammatory mediator levels, indicating that rutin could effectively modulate various inflammatory pathways involved in psoriasis.
9
We explored the potential of rutin, a flavonoid, to tackle rheumatoid arthritis in rats. By administering a 15 mg/kg dose, we observed notable reductions in paw swelling and improvements in blood parameters. Rutin not only increased protective enzymes but also decreased harmful cytokines linked to inflammation.
Additionally, we noted histological improvements, such as reduced joint inflammation and bone erosion. Overall, our findings indicate that rutin shows promise in promoting health in conditions related to arthritis by inhibiting specific inflammatory processes.
Additionally, we noted histological improvements, such as reduced joint inflammation and bone erosion. Overall, our findings indicate that rutin shows promise in promoting health in conditions related to arthritis by inhibiting specific inflammatory processes.
8
Rutin nanoparticles improve arthritis symptoms
We investigated the effects of rutin, a natural flavonoid, in a study designed to evaluate its protective role against rheumatoid arthritis in male rats. The research included various groups, comparing the impact of rutin alone and in nanoparticle form with a control group receiving a standard treatment.
Our findings revealed that rutin nanoparticles successfully reversed signs of oxidative stress and inflammation that arise from rheumatoid arthritis. Improvements in both behavioral assessments and tissue health were noted, suggesting that this interesting delivery system could serve as a promising strategy for managing rheumatoid arthritis effectively.
Our findings revealed that rutin nanoparticles successfully reversed signs of oxidative stress and inflammation that arise from rheumatoid arthritis. Improvements in both behavioral assessments and tissue health were noted, suggesting that this interesting delivery system could serve as a promising strategy for managing rheumatoid arthritis effectively.
Most Useful Reviews
9
Visible improvement achieved
7 people found this helpful
Ruthin Super surprised me; the asterisks on my skin faded. I took Rutin, vitamin C, Gotu Kola, and horse chestnut. Despite initial side effects from the chestnut and Gotu Kola, after a month, the pale stars on my face have almost disappeared. I will definitely continue the course and order again. My weak vessels have always caused headaches, but this treatment is helping.
9
Immediate noticeable effect
3 people found this helpful
Rutin has become my favourite for tackling vascular issues. Initially, I took a domestic version, but I found this one online has a much better effect. You must take it for at least a month for it to accumulate in the body, and while it’s best paired with vitamin C, even without it, I noticed a significant improvement in my vessels.
7.5
Well-being improved
1 people found this helpful
I constantly order Rutin to support my blood vessels, taking it alongside vitamin C. My general well-being has improved significantly; I no longer feel dizzy, and my headaches have become much less frequent. The composition of this supplement is excellent and highly effective; the capsules are medium-sized and easy to swallow.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
- All Researches
9.5
Phlogenzym effective in EAE model
We explored the effects of Phlogenzym, a combination of hydrolytic enzymes and antioxidants, in a mouse model of multiple sclerosis. The treatment demonstrated complete protection against a condition known as experimental allergic encephalomyelitis (EAE).
Notably, it altered the immune response, needing higher levels of specific peptides to activate T cells. This suggests that Phlogenzym raises the activation threshold for those T cells, potentially lowering autoimmune activity. Our findings support Phlogenzym as a viable option for managing some autoimmune disorders.
Notably, it altered the immune response, needing higher levels of specific peptides to activate T cells. This suggests that Phlogenzym raises the activation threshold for those T cells, potentially lowering autoimmune activity. Our findings support Phlogenzym as a viable option for managing some autoimmune disorders.
9
We aimed to investigate how rutin might help manage psoriasis and its underlying mechanisms. By utilizing network pharmacology, we identified 62 potential targets of rutin relevant to psoriasis and assessed its impact on severity using a murine model.
Our results demonstrated that rutin significantly reduced severity scores and improved skin lesions compared to the control group. Furthermore, we found a decrease in key inflammatory mediator levels, indicating that rutin could effectively modulate various inflammatory pathways involved in psoriasis.
Our results demonstrated that rutin significantly reduced severity scores and improved skin lesions compared to the control group. Furthermore, we found a decrease in key inflammatory mediator levels, indicating that rutin could effectively modulate various inflammatory pathways involved in psoriasis.
9
We explored the potential of rutin in alleviating Sjogren's syndrome, an autoimmune disease with unclear treatment options. Using advanced proteomics, we compared proteins in the salivary glands of healthy and Sjogren's-affected mice. Our findings revealed that rutin significantly improved salivary secretion and reduced inflammation in these glands.
Notably, rutin acted on specific signaling pathways, particularly the CaR/NLRP3/NF-κB pathway. However, it is important to highlight that further research is needed, particularly regarding the role of calcium-sensing receptors in this process.
Notably, rutin acted on specific signaling pathways, particularly the CaR/NLRP3/NF-κB pathway. However, it is important to highlight that further research is needed, particularly regarding the role of calcium-sensing receptors in this process.
9
We explored how rutin, a natural compound known for its health benefits, affects lupus nephritis, a common complication of the autoimmune disorder systemic lupus erythematosus (SLE). Using MRL/lpr mice, we treated them with rutin and observed a notable reduction in harmful serum cytokines and autoantibodies.
Additionally, rutin helped decrease inflammation in kidney tissues. Our laboratory experiments suggested that rutin alleviates oxidative stress in T cells and activates mechanisms that regulate inflammation through PPARγ. Overall, the findings indicate that rutin may offer therapeutic potential for managing lupus nephritis.
Additionally, rutin helped decrease inflammation in kidney tissues. Our laboratory experiments suggested that rutin alleviates oxidative stress in T cells and activates mechanisms that regulate inflammation through PPARγ. Overall, the findings indicate that rutin may offer therapeutic potential for managing lupus nephritis.
9
We evaluated how rutin, a flavonoid known for its antioxidant and neuroprotective properties, could benefit mice with induced multiple sclerosis (MS). In our study, we compared rutin with the standard drug dimethyl fumarate while observing the effects on motor functions and neural damage.
The results were encouraging, demonstrating that rutin significantly improved locomotion, motor coordination, and remyelination in the brain. It also reduced oxidative stress and inflammation more effectively than the competitor drug.
This suggests that rutin has potential as a supplemental treatment for MS.
The results were encouraging, demonstrating that rutin significantly improved locomotion, motor coordination, and remyelination in the brain. It also reduced oxidative stress and inflammation more effectively than the competitor drug.
This suggests that rutin has potential as a supplemental treatment for MS.
User Reviews
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Visible improvement achieved
7 people found this helpful
Ruthin Super surprised me; the asterisks on my skin faded. I took Rutin, vitamin C, Gotu Kola, and horse chestnut. Despite initial side effects from the chestnut and Gotu Kola, after a month, the pale stars on my face have almost disappeared. I will definitely continue the course and order again. My weak vessels have always caused headaches, but this treatment is helping.
9
Immediate noticeable effect
3 people found this helpful
Rutin has become my favourite for tackling vascular issues. Initially, I took a domestic version, but I found this one online has a much better effect. You must take it for at least a month for it to accumulate in the body, and while it’s best paired with vitamin C, even without it, I noticed a significant improvement in my vessels.
7.5
Well-being improved
1 people found this helpful
I constantly order Rutin to support my blood vessels, taking it alongside vitamin C. My general well-being has improved significantly; I no longer feel dizzy, and my headaches have become much less frequent. The composition of this supplement is excellent and highly effective; the capsules are medium-sized and easy to swallow.
7.5
Visible vein improvement
1 people found this helpful
After two weeks of use, I ordered this medication for my mother (64 years old). She saw her veins in her arms become less visible. Before using it, her veins were quite prominent. We're looking forward to more significant results after the full course of three months.
9
Bruises disappear quickly
12 people found this helpful
Super!!! Goodbye bruises! If you, like me, have large persistent bruises, rutin will assist you; they vanish in four days. For more of my reviews on other useful Iherb products, you can find them easily. To save money, bookmark my page. I wish you all love, happiness and good health! If this review was helpful, let me know! Be youthful, beautiful, and, of course, happy!
Frequently Asked Questions
9
Visible improvement achieved
7 people found this helpful
Ruthin Super surprised me; the asterisks on my skin faded. I took Rutin, vitamin C, Gotu Kola, and horse chestnut. Despite initial side effects from the chestnut and Gotu Kola, after a month, the pale stars on my face have almost disappeared. I will definitely continue the course and order again. My weak vessels have always caused headaches, but this treatment is helping.
9
Immediate noticeable effect
3 people found this helpful
Rutin has become my favourite for tackling vascular issues. Initially, I took a domestic version, but I found this one online has a much better effect. You must take it for at least a month for it to accumulate in the body, and while it’s best paired with vitamin C, even without it, I noticed a significant improvement in my vessels.
7.5
Visible vein improvement
1 people found this helpful
After two weeks of use, I ordered this medication for my mother (64 years old). She saw her veins in her arms become less visible. Before using it, her veins were quite prominent. We're looking forward to more significant results after the full course of three months.
6
Slow but effective
Good, this is an interesting supplement. Unfortunately, its effects can only be observed after three months, as the impact is slow yet effective. Personally, I believe in the efficacy of the drug, as it is crucial for me to maintain my vessels in good condition.
7.5
Well-being improved
1 people found this helpful
I constantly order Rutin to support my blood vessels, taking it alongside vitamin C. My general well-being has improved significantly; I no longer feel dizzy, and my headaches have become much less frequent. The composition of this supplement is excellent and highly effective; the capsules are medium-sized and easy to swallow.
9
Joint pain relief
2 people found this helpful
I ordered Rutin for my cousin, who suffered from joint pain and night spasms. After two weeks, she noticed a significant improvement; the pain vanished entirely, and the spasms ceased, especially when taken alongside Magnesium Citrate.
7.5
Condition improved
1 people found this helpful
It works! I've ordered for myself and my mother for the second time. It's excellent for dilated capillaries and vascular networks. My mother has seen a significant improvement with Rutin, so we're continuing its use. The effects are there!
7.5
Symptoms improved
5 people found this helpful
I take two tablets daily. I've always had allergies causing itchy eyes, but my symptoms have improved. I will order again.
4
No effect observed
Unfortunately, I ordered Rutin for a friend, and she did not experience the intended benefits. I cannot recommend it based on her experience.
9
We aimed to investigate how rutin might help manage psoriasis and its underlying mechanisms. By utilizing network pharmacology, we identified 62 potential targets of rutin relevant to psoriasis and assessed its impact on severity using a murine model.
Our results demonstrated that rutin significantly reduced severity scores and improved skin lesions compared to the control group. Furthermore, we found a decrease in key inflammatory mediator levels, indicating that rutin could effectively modulate various inflammatory pathways involved in psoriasis.
Our results demonstrated that rutin significantly reduced severity scores and improved skin lesions compared to the control group. Furthermore, we found a decrease in key inflammatory mediator levels, indicating that rutin could effectively modulate various inflammatory pathways involved in psoriasis.
8
We investigated rutin, a flavonoid from Ruta graveolens, for its effects on IgA nephropathy in Sprague-Dawley rats. Our study involved three groups: a control group with no treatment, an induced group receiving only the disease-causing agents, and a treatment group receiving both the agents and rutin.
We found that rutin significantly reduced IgA deposition, inflammation, and fibrosis by blocking specific pathways associated with kidney damage. This suggests that rutin could be beneficial in managing inflammation tied to IgA nephropathy, potentially reducing overall kidney damage.
We found that rutin significantly reduced IgA deposition, inflammation, and fibrosis by blocking specific pathways associated with kidney damage. This suggests that rutin could be beneficial in managing inflammation tied to IgA nephropathy, potentially reducing overall kidney damage.
9
We explored how rutin, a natural compound known for its health benefits, affects lupus nephritis, a common complication of the autoimmune disorder systemic lupus erythematosus (SLE). Using MRL/lpr mice, we treated them with rutin and observed a notable reduction in harmful serum cytokines and autoantibodies.
Additionally, rutin helped decrease inflammation in kidney tissues. Our laboratory experiments suggested that rutin alleviates oxidative stress in T cells and activates mechanisms that regulate inflammation through PPARγ. Overall, the findings indicate that rutin may offer therapeutic potential for managing lupus nephritis.
Additionally, rutin helped decrease inflammation in kidney tissues. Our laboratory experiments suggested that rutin alleviates oxidative stress in T cells and activates mechanisms that regulate inflammation through PPARγ. Overall, the findings indicate that rutin may offer therapeutic potential for managing lupus nephritis.
9
We evaluated how rutin, a flavonoid known for its antioxidant and neuroprotective properties, could benefit mice with induced multiple sclerosis (MS). In our study, we compared rutin with the standard drug dimethyl fumarate while observing the effects on motor functions and neural damage.
The results were encouraging, demonstrating that rutin significantly improved locomotion, motor coordination, and remyelination in the brain. It also reduced oxidative stress and inflammation more effectively than the competitor drug.
This suggests that rutin has potential as a supplemental treatment for MS.
The results were encouraging, demonstrating that rutin significantly improved locomotion, motor coordination, and remyelination in the brain. It also reduced oxidative stress and inflammation more effectively than the competitor drug.
This suggests that rutin has potential as a supplemental treatment for MS.
9
We explored the potential of rutin in alleviating Sjogren's syndrome, an autoimmune disease with unclear treatment options. Using advanced proteomics, we compared proteins in the salivary glands of healthy and Sjogren's-affected mice. Our findings revealed that rutin significantly improved salivary secretion and reduced inflammation in these glands.
Notably, rutin acted on specific signaling pathways, particularly the CaR/NLRP3/NF-κB pathway. However, it is important to highlight that further research is needed, particularly regarding the role of calcium-sensing receptors in this process.
Notably, rutin acted on specific signaling pathways, particularly the CaR/NLRP3/NF-κB pathway. However, it is important to highlight that further research is needed, particularly regarding the role of calcium-sensing receptors in this process.
References
- Li X, Han Y, Liang X, Hu Y, Lang G. Exploring the Therapeutic Potential of Rutin in Psoriasis: Network Pharmacology and Experimental Validation. Comb Chem High Throughput Screen. 2024. 10.2174/0113862073336573240909113013
- Jash R, Maji HS, Chowdhury A, Biswas S, Maparu K, et al. Rutin reduces inflammation and fibrosis via TGF-β/SMAD pathways in IgA nephropathy induced rats. Nephrology (Carlton). 2024;29:717. 10.1111/nep.14378
- He J, Xu M, Wu S. Rutin alleviates Sjogren's syndrome via CaR/NLRP3/NF-κB signal pathway. In Vitro Cell Dev Biol Anim. 2024;60:411. 10.1007/s11626-024-00893-4
- Yi T, Zhang W, Hua Y, Xin X, Wu Z, et al. Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPARγ. Chem Biol Interact. 2024;394:110972. 10.1016/j.cbi.2024.110972
- Nicola MA, Attaai AH, Abdel-Raheem MH, Mohammed AF, Abu-Elhassan YF. Neuroprotective effects of rutin against cuprizone-induced multiple sclerosis in mice. Inflammopharmacology. 2024;32:1295. 10.1007/s10787-024-01442-x
- Gravandi MM, Pourmanouchehri Z, Behbood L, Fakhri S, Mohammadi-Noori E, et al. Rutin-loaded chitosan nanoparticles alleviated Freund's adjuvant induced rheumatoid arthritis via modulating oxidative stress and inflammatory parameters in Wistar rats. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:4771. 10.1007/s00210-023-02902-x
- Quintans-Júnior LJ, Gandhi SR, Passos FRS, Heimfarth L, Pereira EWM, et al. Dereplication and quantification of the ethanol extract of Miconia albicans (Melastomaceae) by HPLC-DAD-ESI-/MS/MS, and assessment of its anti-hyperalgesic and anti-inflammatory profiles in a mice arthritis-like model: Evidence for involvement of TNF-α, IL-1β and IL-6. J Ethnopharmacol. 2020;258:112938. 10.1016/j.jep.2020.112938
- Li CW, Li Q, Guo L, Wu AP, Hu L, et al. [Effect of Rutin on Liver Function and Morphology in Type 1 Diabetes Mice Induced by Streptozotocin]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2018;49:384.
- Sun CL, Wei J, Bi LQ. Rutin Attenuates Oxidative Stress and Proinflammatory Cytokine Level in Adjuvant Induced Rheumatoid Arthritis via Inhibition of NF-κB. Pharmacology. 2017;100:40. 10.1159/000451027
- Nikfarjam BA, Adineh M, Hajiali F, Nassiri-Asl M. Treatment with Rutin - A Therapeutic Strategy for Neutrophil-Mediated Inflammatory and Autoimmune Diseases: - Anti-inflammatory Effects of Rutin on Neutrophils. J Pharmacopuncture. 2017;20:52. 10.3831/KPI.2017.20.003
- Zhang S, Li H, Zhang L, Li J, Wang R, et al. Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats. Brain Res. 2017;1657:355. 10.1016/j.brainres.2016.12.009
- Desser L, Holomanova D, Zavadova E, Pavelka K, Mohr T, et al. Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood. Cancer Chemother Pharmacol. 2001;47 Suppl:S10.
- Ostrakhovitch EA, Afanas'ev IB. Oxidative stress in rheumatoid arthritis leukocytes: suppression by rutin and other antioxidants and chelators. Biochem Pharmacol. 2001;62:743.
- Targoni OS, Tary-Lehmann M, Lehmann PV. Prevention of murine EAE by oral hydrolytic enzyme treatment. J Autoimmun. 1999;12:191.
